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KMID : 0606920130210060454
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Biomolecules & Therapeutics
2013 Volume.21 No. 6 p.454 ~ p.461
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Neuroprotective Effects of a Butanol Fraction of Rosa hybrida Petals in a Middle Cerebral Artery Occlusion Model
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Yang Go-Eun
Park Dong-Sun
Lee Sun-Hee
Bae Dae-Kwon
Yang Yun-Hui
Kyung Jang-Been
Kim Da-Jeong
Choi Ehn-Kyoung
Hong Jin-Tae
Jeong Heon-Sang
Kim Hee-Jung
Jang Su-Kil
Joo Seong-Soo
Kim Yun-Bae
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Abstract
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The neuroprotective effects of a butanol fraction of white rose petal extract (WRPE-BF) were investigated in a middle cerebral artery occlusion (MCAO) model. Seven week-old male rats were orally administered WRPE-BF for 2 weeks and subjected to MCAO for 2 h, followed by reperfusion. Twenty-four h later, MCAO-induced behavioral dysfunctions were markedly improved in a dose-dependent manner by pretreatment with WRPE-BF. Moreover, higher dose of WRPE-BF not only decreased infarction area but also effectively reduced astrogliosis. The expression of inducible nitric oxide synthase, cyclooxygenase-2, and glial fibrillary acidic protein in MCAO model were markedly inhibited by WRPE-BF treatment. Notably, WRPE-BF decreased nitric oxide and malondialdehyde levels in the striatum and subventricular zone of stroke-challenged brains. These data suggested that WRPE-BF may exert its neuroprotective effects via anti-oxidative and anti-inflammatory activities against ischemia-reperfusion brain injury and could be a good candidate as a therapeutic target for ischemic stroke.
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KEYWORD
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Ischemic brain injury, Middle cerebral artery occlusion, Glial fibrillary acidic protein, Rosa hybrida, Antioxidation, Anti-inflammation
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